We were surprised to discover that of the five cuproptosis-related lncRNAs (VIM-AS1, AC012443.2, MALINC1, AL354696.2, HSD11B1-AS1), except for AC012443.2 and AL354696.2, which have no related studies previously published, the other three were shown to be closely associated with cancer progression, especially SKCM. The gene discussed is HSD11B1; the disease is cancer.