TP53 and diabetes mellitus: Researchers constructed a mouse model with a specific deletion in pancreatic cells (arf-bp1FL/Y/RIP-cre) and found that the mice died of severe diabetes as they matured; in contrast, when the p53 deletion was reversed (p53LFL/FL/arf-bp1FL/Y/RIP-cre), the mice lived longer (Kon et al., 2012).