Our chromatin interaction data also revealed that BLK promoter interacts haplotype-specifically with a distal repressor REST binding site and the FAM167A gene promoter, with the interactions being stronger on the SLE risk haplotype (Figures 2,3), consistent with reduced expression of BLK on the risk haplotype, and the hypothesis that BLK promoter is “enhancer-like” and may regulate expression of FAM167A, respectively. This evidence concerns the gene REST and systemic lupus erythematosus.