Focusing specifically on the FAM167A-BLK locus, we found that the BLK promoter and the enhancer E3 located 52 kb downstream from the promoter haplotype-specifically interact in the 3D chromatin context, with the interaction being weaker on the SLE risk haplotype, consistent with the reduced expression of BLK on the risk haplotype (Figures 2,3). This evidence concerns the gene BLK and systemic lupus erythematosus.