In conclusion, by comprehensively elucidating the expression, prognostic value, association with clinicopathological factors, co-expression network, pathway enrichment analysis, and crosstalk with immune infiltration in HCC, LECT2 may be a new potential prognostic and diagnostic biomarker for hepatocellular carcinoma with potential clinical applications. This evidence concerns the gene LECT2 and hepatocellular carcinoma.