CD274 and neoplasm: For example, TAS0314 long-chain peptide vaccine has been found to have a synergistic anti-tumor immune effect with PD-1/PD-L1, which can enhance the therapeutic effect of PD-1/PD-L1 blockage by promoting the infiltration of cancer-specific cytotoxic T lymphocytes (CTLs) in tumor tissues (Tanaka et al., 2020).