Indeed, Sajadian et al. (2015) showed that the active demethylation by anti-cancer DNMTi, 5-azacytidine, is TET2 dependent, while Cimmino et al. (2017)restored sensitivity of TET2-deficient cancer cells to PARPi by increasing the abundance of 5 hmC using ascorbic acid. Here, TET2 is linked to cancer.