Many studies indicated that methylation levels were closely correlated with tumor development, cancer progression, and chemotherapy and immunotherapy sensitivity of HCC (Al-Abdulla et al., 2019; Dong et al., 2021; Zhong et al., 2021; Liu et al., 2022) Thus, to explore the mechanism for the aberrant expression of MJDs family members in HCC, we further analyzed the correlations between these genes expression levels and promoter methylation levels with the UALCAN database. This evidence concerns the gene LPIN2 and hepatocellular carcinoma.