The KEGG pathways showed that for ATXN3, ubiquitin mediated proteolysis, fanconi anemia pathway, aminoacyl-tRNA biosynthesis and RNA transport were significantly up-regulated, whereas valine, leucine and isoleucine degradation, staphylococcus aureus infection, glycine serine and threonine metabolism were significantly down-regulated (Figure 12C). This evidence concerns the gene ATXN3 and staphylococcus aureus infection.