The results demonstrated that the Spearman coefficients of ATXN3, JOSD1, and JOSD2 were -0.31,-0.35, and -0.29, respectively, indicating negative association between the methylation levels and the mRNA transcriptional levels of these three genes in HCC patients (Figures 4A–C). This evidence concerns the gene JOSD1 and hepatocellular carcinoma.