Overexpression of FGF18, relating to the embryonic and postnatal development of cartilage, hair, and vasculature, plays an important role in the process of invasion and metastasis of several neoplasms, including hepatocellular carcinoma (Guo et al., 2018), gastric cancer (Zhang et al., 2019a), and colon cancer (Shimokawa et al., 2003), while high expression of FGF18 correlates with a good prognosis in ccRCC patients (Yang et al., 2020). This evidence concerns the gene FGF18 and colonic neoplasm.