VEGFA and breast carcinoma: VEGF polymorphisms have also been found to be significantly associated with susceptibility and aggressiveness of breast cancer (Rahoui et al., 2014; Sa-Nguanraksa et al., 2014), as well as prognosis of non-small-cell lung cancer (Heist et al., 2008), gastric cancer (Tzanakis et al., 2006) and esophageal cancer (Bradbury et al., 2009).