TP53 and autoimmune thyroid disease: GSEA showed that genes were significantly enriched on DNA replication, homologous recombination, mismatch repair, pyrimidine metabolism, and the p53 signaling pathway in the high-risk group and asthma, intestinal immune network, autoimmune thyroid disease, hematopoietic cell lineage, and arachidonic acid metabolism in the low-risk group (Figure 5D).