CD4 and infection: To gain a better understanding into the dynamic roles of distinct lymphocyte subsets during acute and secondary infection in this novel hepacivirus mouse model we performed a high-dimensional flow cytometry analysis of lymphocyte subsets including CD4+ T cells, CD8+ cells, NK cells and NKT cells from blood, spleen and liver of C57BL/6 mice at multiple time points during infection and age-matched controls (experimental outline: Figures S1A, B).