In a murine study assessing the use of CD40-B cells as an anti-cancer vaccine, vaccination of wild-type mice with LCMV antigen-pulsed CD40-B cells significantly reduced growth of LL-LCMV subcutaneous tumors by direct and indirect activation of CD8 T cells, but antigen-pulsed LPS-activated B cells did not (205). The gene discussed is CD40; the disease is cancer.