Furthermore, MIS-C represents a cytokine storm induced by SARS-CoV-2 with elevated inflammatory markers, including C-reactive protein (CRP), procalcitonin, neutrophilia, lymphopenia, and pro-inflammatory cytokine levels (i.e., IL-6, IL-10, ferritin, and D-dimers), that often meets the criteria for macrophage activation syndrome (MAS) of children and shares certain characteristics with KD (3, 24, 25). This evidence concerns the gene IL10 and macrophage activation syndrome.