Compared with the group without APS, the expression levels of p-STAT1 and p-STAT3 in MDSC increased significantly with increasing APS concentrations (from 80 μg/ml to 160 μg/ml), with MFI values of (374.67 vs 696.50 vs 853.17, p< 0.001) (Figures 8A, B), and (119.00 vs 147.67 vs 182.50, p< 0.001), respectively (Figures 8C, D). Here, STAT3 is linked to autoimmune polyendocrinopathy.