Direct exposure of APS to splenocytes, increased the expression levels of interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-6 (IL-6), and interferon (IFN)-γ in macrophages, helper T cell (Th) cells, and NK cells. This evidence concerns the gene IL6 and autoimmune polyendocrinopathy.