TNF and neoplasm: The expression and function of CD73 are elevated in the presence of hypoxia and inflammatory mediators (TGF- B, IFNs, TNF-α, IL-1B, PGE2, etc.), and the expression of CD73 is also increased in several tumor tissues, suggesting that CD73 is involved in tumor genesis and development (2, 13, 14, 19), eATP is decomposed into eADO through the sequence of CD39 and CD73, which bind to adenosine receptors on the cell membrane surface (2, 13, 14).