NT5E and neoplasm: In an immunoactive mouse tumor model, MEDI9447 reduces immunosuppressive effects and promotes antineoplastic function (45); BMS986179, a high affinity antibody, inhibits the activity of CD73 and mediates the internalization of CD73 (19, 69); CPI-006 (also known as CPX006) acts mainly by inhibiting CD73 activity and/or inducing CD73 downregulation; IPH5301, which blocks AMP from degrading to the immunosuppressant adenosine.