Moreover, tumor cells remained suppressed after re-inoculation of mice with tumor cells, suggesting that CPI-444 induces systemic antineoplastic immune memory and that the combination of CPI-444 with CTLA-4 mAb increases the presence of CD8+T cells and IFNγ and Gzm B levels in tumors (71). This evidence concerns the gene CTLA4 and neoplasm.