The high expression of CD73 on the surface of tumor cells shows a weaker effect of immunotherapy with a PD-1 antibody, and the combined use of PD-1 mAb and CD73 mAb prominently inhibited tumor growth (46), and increased gene expression related to inflammation and T cell function, causing an increase in the number and activity of tumor-infiltrating CD8+T cells and the production of IFN-γ and TNF-α (20, 46). The gene discussed is TNF; the disease is neoplasm.