The expression of IGFBP2 in normal tissues was significantly higher than that in ESCA tissues as confirmed by qRT-PCR; IGFBP2 is involved in various oncogenic processes, such as epithelial-to-mesenchymal transition, cell migration, invasion, angiogenesis, stemness, transcriptional activation, epigenetic programming, etc. A recent study showed that rs1470579 CC genotype IGFBP2 is protective against adenocarcinoma of the esophagogastric junction (24). Here, IGFBP2 is linked to adenocarcinoma.