GZMB and neoplasm: In this case the EpCAM/CD3 molecule induced Granzyme B on TILs and the secretion of cytokines in the culture media (Supplemental Fig. 3 A-C), demonstrating that the LY6G6D/CD3 TcE is specific, and the lack of T cell activation is not due to a defect on T cells, since they can be activated in the presence of EpCAM/CD3 TcE in EpCAM positive tumor samples.