GEM efficiently depleted Ly6Chi monocytes in PB of OM-MOG EAE at dpi 15, and of both Ly6Chi and Ly6G+ cells on dpi 28, confirming these cells are highly proliferating (Figure 3B), and this correlated with extended protection against disease by OM-MOG (Figure 3A). This evidence concerns the gene MOG and ocular melanoma.