So far, these results show that OM-MOG does not alter CCR2 production by peripheral Ly6Chi cells, and that even a single injection of soluble OM-MOG is sufficient to induce MHCII and PD-L1 production by circulating Ly6Chi monocytes and to prevent their migration to the spinal cord to induce EAE. This evidence concerns the gene CCR2 and ocular melanoma.