FCER2 and chronic rhinosinusitis with nasal polyps: Thus, distinguishing from the oligoclonal IgE in AR, which only reacts to specific antigens, the IgE in NPs is polyclonal, which reacts to multiple antigens and derives from many B cells; Then, the polyclonal IgE can initiate mediators releasing via interactions with FcεRI on mast cells or FcεRII(CD23) on basophil, finally contributing to the persistent local inflammation in CRSwNP.