Thus, distinguishing from the oligoclonal IgE in AR, which only reacts to specific antigens, the IgE in NPs is polyclonal, which reacts to multiple antigens and derives from many B cells; Then, the polyclonal IgE can initiate mediators releasing via interactions with FcεRI on mast cells or FcεRII(CD23) on basophil, finally contributing to the persistent local inflammation in CRSwNP. This evidence concerns the gene IGHE and chronic rhinosinusitis with nasal polyps.