The levels of IgG, IgG subclasses(IgG1, IgG2, IgG3, and IgG4), IgM, IgE, and IgA were significantly increased in polyps compared with CRSsNP and controls samples, and showed little correlation with serum Ig levels (13). This evidence concerns the gene CD79A and chronic rhinosinusitis without nasal polyps.