In CRSwNP, factors promoting the activation of B cells include inflammatory cytokines [i.e., IL-5 (36), IL-6, BAFF, and APRIL(a proliferation-inducing ligand)], chemokines [C-X-C motif ligand 12(CXCL12), C-X-C motif ligand 13(CXCL13)], and complement pathway products(C3d) (63, 64). Here, TNFSF13B is linked to chronic rhinosinusitis with nasal polyps.