For instance, ALKBH1, ALYREF, DNMT1, DNMT3A, DNMT3B, NOP2, NSUN2, NSUN3, NSUN4, NSUN5, TET1, TET2, TET3, TRDMT1, and YBX1 were up-regulated in HCC, while DNMT3L, NSUN6, and NSUN7 were down-regulated (Figure 2A). Here, ALYREF is linked to hepatocellular carcinoma.