As a key adaptor molecule in the downstream signaling of several C-type lectin receptors, CARD9 deficiency may lead to different fungal infections, including mucocutaneous or invasive candidiasis, deep dermatophytosis, phaeohyphomycosis, extrapulmonary aspergillosis, mucormycosis and trichosporosis (10–15). This evidence concerns the gene CLEC4D and fungal infectious disease.