As a key adaptor molecule in the downstream signaling of several C-type lectin receptors, CARD9 deficiency may lead to different fungal infections, including mucocutaneous or invasive candidiasis, deep dermatophytosis, phaeohyphomycosis, extrapulmonary aspergillosis, mucormycosis and trichosporosis (10–15). The gene discussed is CLEC4D; the disease is Zygomycosis.