The majority of 122 highly expressed immunomodulators were found in the high SIGLEC15 mRNA expression group, such as MHC family member genes, CXC family member genes, CXC chemokine receptors that played important roles in cancer immunity (Figure 4A), and ICPs and ICD genes, which played critical roles in modulating the host antitumor immunity. The gene discussed is HLA-C; the disease is cancer.