Consistent with our result, previous studies through integrative data mining of SIGLEC15 mRNA expression in human tumors showed that higher SIGLEC15 levels were observed in colon adenocarcinoma and thyroid carcinoma (60), colon adenocarcinoma, esophageal carcinoma and thyroid carcinoma (61). The gene discussed is SIGLEC15; the disease is colon adenocarcinoma.