In contrast, no significant changes were found in the co-culture of mutant HMy2.CIR with HMC (Figures S3A, B) and HK2 cells (Figure S4), which showed no alteration in expression of megsin (a HMC marker) that is involved in the renal tissues of various glomerular diseases (29) and expression of IL1β, RANTES, MCP-1, and TIM-1 by HK2 cells. The gene discussed is SERPINB7; the disease is glomerular disorder.