CD68 and cancer: It is well known that M1 macrophages promote the attack on tumor cells, while M2 macrophages have been consistently associated with cancer metastasis and poor prognosis (48), but it has also been suggested that CD68+ HLA-DR+ M1-type macrophages in the tumor microenvironment can promote tumor migration through the NF-KB signaling pathway, which in turn promotes tumor progression (49).