In our results, TAM infiltration was relatively high in the high-NRGPS group and was abundant in immune cells recruited by NRGPS, AXL, RAI14, and NOX4, and in the combined TAM and NRGPS analysis results, we found that GC patients in the high-TAM and high-NRGPS groups had the shortest survival times.M1-like macrophages and M2-like macrophages are the two main classifications of activated macrophages. The gene discussed is NOX4; the disease is gastric cancer.