SOX2 and neoplasm: We further assessed the RNA-sequencing data of tumor tissues from GBM patients in the Department of Neurosurgery, Qilu Hospital, Shandong University to calculate each patient’s SNHGscore (Figure S7H); The results showed that tumor tissues from patients with a high SNHGscore had lower SOX2 expression and higher CD44 expression, corresponding to the MES subtype.