The PRY/SPRY domain of TRIM21 interacts with γ-interferon-inducible protein-16 (IFI16) and mediates the degradation of IFI16 in a K33-linked manner, leading to the inhibition of cell pyroptosis and self-escape from immune surveillance, which may account for the occurrence of cervical cancer (73, 74). Here, IFI16 is linked to cervical carcinoma.