What’s more, there is only a clinical trial related to TRIM21 as” Prognostic Value of Anti-Ro52 Antibodies in Connective Tissue Diseases (a-Ro52) (a-Ro5)” (ClinicalTrials.gov Identifier: NCT03565601), it is of great potential and need to develop agonists or inhibitors targeting TRIM21 for cancer treatments. This evidence concerns the gene TRIM21 and cancer.