There were few intersections of genes correlated with M2 in Macro1 and Macro3, except for ALOX15B/12B (Figure 2F), possibly indicating a functional transition of M2 macrophages in different classes of gliomas, with macrophages relying on ALOX15B for leukotriene synthesis in Macro3, which represents the lower grade, and ALOX15B and ALOX5/ALOX5AP in the higher grade. The gene discussed is ALOX15B; the disease is glioma.