IDH3A and central nervous system cancer: At the molecular pathogenesis level, the status of isocitrate dehydrogenase (IDH) gene mutation and chromosome arm 1p19q deletion defines three types of invasive gliomas: IDH-mutant with 1p19q co-deleted, IDH mutant with 1p19q non-co-deleted, and IDH wild-type glioma, greatly advancing our knowledge of the etiology (1, 7, 8).