ACACA and central nervous system cancer: As a result, Macro1 had significantly downregulated genes involved in the de novo FA synthesis, particularly ACACA, FASN, SCD, and SREBF1/2, and upregulated genes involved in FA uptake, such as CD36, SLC27A3, FABP5, and FABP7 (Figures S3A, S3B), while the opposite was true for Macro3, possibly indicating the heterogenous FA sources between glioma groups.