OSM and Insulin resistance: Genes of interest include Ccrl2, an atypical chemokine receptor rapidly upregulated during inflammation (36); Osm, a cytokine that contributes to hepatic insulin resistance, fibrosis, development of NASH, and hepatocellular carcinoma (37–39); and Ccl3, a chemokine that favors the progression of steatohepatitis via macrophage recruitment (40).