Additionally, a phase 3 clinical trial (IMpower130) showed a significant improvement in OS and progression-free survival in stage IV NSCLC patients who received atezolizumab (anti-PD-L1 mAb), in combination with chemotherapy (carboplatin plus Nab-paclitaxel) compared to patients receiving standard-of-care chemotherapy alone (21). The gene discussed is CD274; the disease is non-small cell lung carcinoma.