For instance, a preclinical study using the adenovirus-based vaccine targeting the carcinoembryonic antigen Ad-CEA, which is an oncofetal tumor antigen, in combination with N-803, an IL-15 superagonist complex consisting of an IL-15 mutant (IL-15N72D) bound to an IL-15 receptor α/IgG1 Fc fusion protein (130–132), showed improved immune response and antitumor activity in a CEA-expressing MC38 murine colon carcinoma model (51). Here, CEACAM5 is linked to colon carcinoma.