CD276 and congenital rubella syndrome: However, in the testing group, high expression of B7-H3 acted as an independent risk factor both for both unfavorable OS [HR=3.47, 95% CI (1.69 to 7.12), P=0.001] and CRS [HR=4.61, 95% CI (2.1 to 10.12), P<0.001].