Compared with IDH1mt glioma tissues with low-risk scores, those with high-risk scores in TCGA exhibited a high proportion of naïve B cells, plasma cells, CD8 T cells, CD4 memory activated T cells, activated NK cells, M0 macrophages, and M1 macrophages, while the proportion of resting NK cells and activated dendritic cells was reduced (Figure 9C). The gene discussed is CD4; the disease is glioma.