The any grade irAEs were pneumonitis (n=8; 8.08%), hypothyroidism (n=5; 5.05%), rash (n=3; 3.03%), diarrhea (n=3; 3.03%), myositis (n=2; 2.02%), increased alanine aminotransferase (n=2; 2.02%), myocarditis (n=1; 1.01%), and hypophysitis (n=1; 1.01%). The gene discussed is GPT; the disease is hypophysitis.