Among these 90 genes, 11 genes were previously identified as driver mutations in colorectal cancer, including PIK3CA, APC, BRAF, KRAS, TP53, FBXW7, AMER1, TCF7L2, SOX9, ARID1A, and SMAD4 (Supplementary Table S2). The gene discussed is TCF7L2; the disease is colorectal cancer.