Studies in tumor metabolism revealed that B7-H3 increases the expression levels of hypoxia-inducible factor 1 α (HIF1α), lactate dehydrogenase A (LDHA), and pyruvate dehydrogenase kinase 1 (PDK1), and therefore stimulates the Warburg effect by increasing glucose uptake and lactate production (130). The gene discussed is PDK1; the disease is neoplasm.