In B-cell non-Hodgkin’s lymphoma patients, the response rates (RRs) of PD-1 blockade are comparatively low, and these patients display increased CD8+ and CD4+ T effector memory cells expressing TIGIT and PD-1 with limited IFN-γ, TNF-α, and IL-2 production (104). The gene discussed is PDCD1; the disease is B-cell non-Hodgkin lymphoma.