And the loss of IL-2R signaling can cause autoimmune diseases (28).In our study, we found that IL-2 is an independent risk factor for disease progression(P<0.005), patients with decreased serum IL-2 levels and increased TBIL levels have a remarkable higher incidence of liver failure and poorer prognosis, which was verified by the ROC curve of IL-2 combined with TBIL, with an AUC of 0.781. The gene discussed is IL2RA; the disease is liver failure.