These findings are congruent with our experimental results which found that the reduction of IL-2 in patients with PBC liver failure will lead to the decrease of Th1 type cells (TNF-alpha in the blood is close to the normal value), the Th2 type cells (the decrease of IL-4 in blood compared with the normal control), and the Th17 type cells. This evidence concerns the gene TNF and Hepatic failure.