Susceptibility to nontuberculous mycobacteria (NTM) infection, talaromycosis, histoplasmosis, cryptococcosis, melioidosis, and nontyphoidal salmonellosis has been reported in IFN-γ knockout mice or in patients with IFN-γ signaling defects, such as MSMD (Erb et al., 1999; Tang et al., 2010; Lee et al., 2013; Chi et al., 2016). This evidence concerns the gene IFNG and histoplasmosis.