The vast majority of T. marneffei cases are diagnosed in HIV-positive patients (Supparatpinyo et al., 1994; Kawila et al., 2013), while cases have also been described in other immunocompromised individuals, such as patients with adult-onset acquired immunodeficiency due to autoantibodies against interferon-gamma (IFN-γ) (Guo et al., 2020), various inborn errors of immunity (IEI) (Tangye et al., 2020), hematological malignancies, diabetes mellitus and those taking corticosteroids or immunosuppressive agents (Qiu et al., 2015). The gene discussed is IFNG; the disease is diabetes mellitus.