In the disrupted PCOS rats, OE oral treatment effectively relieved estradiol-induced PCOS rats via: (1) its endocrine balancing on GnRH, FSH, and LH, (2) its antioxidant properties ontheovary caused by OE's useful compounds like pulegone, thymol, and L-menthone, and (3) its huge anti-inflammatory properties. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.