PLOD1 and anovulation: Generally, PCOS cases show different symptoms; among the most important symptoms are abnormal and irregular cycles, abnormality in facial hair growth, infertility and subfertility, overweight, increase in androgen (clinical or biochemical), anovulation or oligovulation, and dysfunctions in hypothalamus, pituitary, and ovarian glands (accompany by increased LH and testosterone and decreased FSH and estrogen as the main multifactorial disorders) together with insulin resistance [4, 5].