In the present study, the 2h postprandial blood glucose level in group D was significantly lower than that in group B. The daily dose of insulin in group C was significantly lower than that in group A. During the treatment period, there were significant differences in the frequency of hypoglycemia among the four groups (P < 0.05), and the frequency of hypoglycemia in group C and D was significantly lower than that in group A (P < 0.05). Here, INS is linked to Hypoglycemia.