CASP2 and liver cancer: The results of western blotting showed that compared with the HepG2 group, the apoptosis-related proteins (Bax and cleaved caspase-2) of liver cancer cells in pHBV1.3 + HepG2 group was much lower, which was upregulated by si-hsa_circ_0000847 (Figures 4(b)–4(c)).