Moreover, compared with the HepG2.2.15 group, the expression of Bax and cleaved caspase-2 of liver cancer cells in si-hsa_circ_0000847 + HepG2.2.15 group was significantly increased, while the expression of Bcl-2 was decreased (Figures 4(b)––4(c)). The gene discussed is BAX; the disease is liver cancer.