The outcomes showed that 22 bioactive compounds and 314 corresponding targets significantly contributed to the antidiabetic effects of P. ginseng via regulating diabetes-related signaling pathways and biological processes, such as insulin resistance, the HIF-1 signaling pathway, the PI3K/Akt signaling pathway, the prolactin signaling pathway, the Rap1 signaling pathway, the Ras signaling pathway, the calcium signaling pathway, and the FoxO signaling pathway. This evidence concerns the gene PIK3CA and diabetes mellitus.