GSDMA and cancer: The published evidence indicates that the murine mammary carcinoma cell line 4T1 undergoes pyroptosis after treatment with NP-GSDMA3 and Phe-BF3 (inducing the release of GSDMA3 after NP-GSDMA3 enters cancer cells), and this effect is accompanied by elevated levels of gasdermin N-termini (Pulaski and Ostrand-Rosenberg, 2001; Wang Q. et al., 2020; Hsu et al., 2021).