In 75 out of 266 prostate cancer patients with overall survival of the first-line AR-targeted inhibitors treatment in the Abida-Wassim study25, higher expression of ARHGEF2 (p = 0.041), LHX2 (p = 0.0091), and EPHB2 (p = 0.15) showed correlation with shortened overall survival time (Fig. 5b), while DPYSL3, EPHB2, FYN, and GNG4 did not positively correlate with shortened overall survival. Here, ARHGEF2 is linked to Familial prostate cancer.