A hierarchical clustering heatmap demonstrated that NLS genes significantly clustered in the group of small cell or adenocarcinoma with NE features in the Abida-Wassim cohort (Fig. 4a, b), which align with upregulation patterns of the aforementioned Beltran NEPC classifier genes and downregulation of AR related genes (Supplementary Fig. 3a). The gene discussed is AR; the disease is adenocarcinoma.