The control set is given routine ministration care, and the examination set is given routine ministration to implement health education; these indicators include: the blood pressure control compliance, Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), and the Chinese version of Perceived Stress Scale (CPSS) scores; the compliance rate of health knowledge score, serum Angiotensin II (Ang II), Endothelin-1 (ET-1) and Superoxide Dismutase (SOD) standards, medication compliance, prognosis quality of life, and cumulative occurrence of MACCE are compared. The gene discussed is EDN1; the disease is major depressive disorder.