ERBB2 and breast carcinoma: The SAFE-HEaRt (Cardiac Safety of HER2 Targeted Therapy in Patients with HER2 Positive Breast Cancer and Reduced Left Ventricular Function) study was the first prospective study to demonstrate safety of Human Epidermal growth factor Receptor 2 (HER-2) targeted therapies in patients with reduced cardiac function (LVEF 40%–49%) [53].