This study aims to analyse the serological profile of soluble EGFR (sEGFR) in different breast cancer subgroups and its possible value as a prognostic marker, and to verify the relationship of sEGFR with clinicopathological variables and with the EGFR present in the tumour cell [tumour EGFR (tEGFR)]. Here, EGFR is linked to neoplasm.