The genome-wide association between m6A-SNPs and ischemic stroke by excavating data from a large-scale GWAS, rs2013162 and rs2273235 may exert its effects by altering the methylation level of m6A and regulating the expression of downstream gene IRF6 and NDST1 respectively, which were potential cause gene of ischemic stroke (56). The gene discussed is IRF6; the disease is ischemic stroke.