Integrative analysis was used to screen for candidate m6A PD risk loci, and identified five m6A-SNPs (rs75072999 of GAK, rs1378602, rs4924839 and rs8071834 of ALKBH5, and rs1033500 of C6orf10) may be associated with PD risk (92), while GAK contributes to the deposition of neurotoxic a-synuclein aggregates in PD (93). This evidence concerns the gene TSBP1 and Parkinson disease.