Next, when examined for the mechanism by which SH005S7 proves its effects against lung cancer in cell culture or in animal models, we found that SH005S7 is a potent inhibitor of the RTK-MEK/EGFR/HER3 activation and related gene products, which has been closely linked to proliferation and chemoresistance in NSCLC. The gene discussed is ERBB3; the disease is non-small cell lung carcinoma.