The individual RTK family signaling molecules initiate several signal transduction cascades, mainly the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) and phosphoinositide-3-kinase/protein kinase B (PI3K/AKT) pathways, leading to DNA synthesis, survival, cell proliferation, angiogenesis, tumor cell motility, invasion, and metastasis in the cancer [16–22]. Here, MAPK1 is linked to cancer.