Next, when examined for the mechanism by which SH005S7 proves its effects against lung cancer in cell culture or in animal models, we found that SH005S7 is a potent inhibitor of the RTK-MEK/EGFR/HER3 activation and related gene products, which has been closely linked to proliferation and chemoresistance in NSCLC. This evidence concerns the gene ERBB3 and lung carcinoma.