ESR1 and neoplasm: Through the visualization of PPI protein network analysis and Cytoscape software, we can see that the key targets of PR extract on cancer are TNF, CASP3, JUN, EGFR, ESR1, HSP90AA1, PPARG, PTGS2, MTOR, etc. TNF is a tumor necrosis factor, which is a cytokine that can directly kill tumor cells, but has no obvious toxic effect on normal cells.