TP53 and central nervous system cancer: Kaposi sarcoma-associated herpesvirus infection regulates proliferation of glioma stem-like cells [62], relieves the Warburg effect through p53 activation, thereby inhibiting breast cancer cell growth [63], inhibits renal cancer cell growth by regulating the p53 signaling pathway [48], suppresses lung cancer growth by activating the p53 signaling pathway [64], promotes cholangiocarcinoma cell proliferation, migration, and invasion by decreasing p53 expression [65], and promotes pancreatic cancer growth and metastasis through the p53 transcriptional pathway [66].