Based on TCGA samples and the UALCAN website, EPC1 expression in HPV positive HNSCC tumors was not only significantly higher than that in paracancerous tissues (P < 0.01) but also significantly higher than that in HPV negative HNSCC samples (P < 0.01) (Figure 1(c)). This evidence concerns the gene EPC1 and head and neck squamous cell carcinoma.