Consistent with CICs contributing to tumor immune escape, research on emperitosis demonstrated that noncytotoxic effector cells exhibit entotic cell death as tumor cells die inside their neighbors, while only cytotoxic effector cells inside undergo apoptotic death because of the reuptake of their own secreted granzyme B. Granzyme B is the cytotoxic granule secreted by cytotoxic T lymphocytes (CTL) and natural killer cells (NK) during elimination of tumor cells and can induce apoptosis [25]. Here, GZMB is linked to neoplasm.